Seneca Valley Virus
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چکیده
Cleaning and Disinfecting The efficacy of most disinfectants against SVV is not clearly known. Because vesicular diseases are clinically indistinguishable, disinfection protocols for FMDV should be followed even if SVV is suspected. This includes use of: sodium hydroxide, sodium carbonate, 0.2% citric acid, aldehydes, and oxidizing disinfectants including sodium hypochlorite. Below are EPA-approved disinfectants USDA lists effective for FMD on page 30 http://www.aphis.usda.gov/animal_health/emergency_management/downloads/fad_epa_disinfect ants.pdf. Be sure to follow labeled directions.
منابع مشابه
Complete Genome Sequence of Seneca Valley Virus CH-01-2015 Identified in China
The complete genome sequence of Seneca Valley virus (SVV), a single-stranded RNA virus that causes porcine vesicular disease in China, has been sequenced and analyzed. This Chinese isolate shares 94.4 to 97.1% sequence identity to another 8 strains from Canada, Brazil, and the United States. This is the first report of SVV infecting swine in China.
متن کاملOncolytic Seneca Valley Virus: past perspectives and future directions
Seneca Valley Virus isolate 001 (SVV-001) is an oncolytic RNA virus of the Picornaviridae family. It is also the first picornavirus discovered of the novel genus Senecavirus. SVV-001 replicates through an RNA intermediate, bypassing a DNA phase, and is unable to integrate into the host genome. SVV-001 was originally discovered as a contaminant in the cell culture of fetal retinoblasts and has s...
متن کاملSeneca Valley Virus 3C Substrate Optimization Yields Efficient Substrates for Use in Peptide-Prodrug Therapy
The oncolytic picornavirus Seneca Valley Virus (SVV-001) demonstrates anti-tumor activity in models of small cell lung cancer (SCLC), but may ultimately need to be combined with cytotoxic therapies to improve responses observed in patients. Combining SVV-001 virotherapy with a peptide prodrug activated by the viral protease 3C is a novel strategy that may increase the therapeutic potential of S...
متن کاملSeneca Valley Virus 3Cpro Substrate Optimization Yields Efficient Substrates for Use in Peptide-Prodrug Therapy
The oncolytic picornavirus Seneca Valley Virus (SVV-001) demonstrates anti-tumor activity in models of small cell lung cancer (SCLC), but may ultimately need to be combined with cytotoxic therapies to improve responses observed in patients. Combining SVV-001 virotherapy with a peptide prodrug activated by the viral protease 3Cpro is a novel strategy that may increase the therapeutic potential o...
متن کاملComplete genome sequence analysis of Seneca Valley virus-001, a novel oncolytic picornavirus.
The complete genome sequence of Seneca Valley virus-001 (SVV-001), a small RNA virus, was determined and was shown to have typical picornavirus features. The 7280 nt long genome was predicted to contain a 5' untranslated region (UTR) of 666 nt, followed by a single long open reading frame consisting of 6543 nt, which encodes a 2181 aa polyprotein. This polyprotein could potentially be cleaved i...
متن کاملIdentification and Complete Genome of Seneca Valley Virus in Vesicular Fluid and Sera of Pigs Affected with Idiopathic Vesicular Disease, Brazil.
Numerous, ongoing outbreaks in Brazilian swine herds have been characterized by vesicular lesions in sows and acute losses of neonatal piglets. The complete genome of Seneca Valley virus (SVV) was identified in vesicular fluid and sera of sows, providing evidence of association between SVV and vesicular disease and viraemia in affected animals.
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